Myelofibrosis

Taking Jakafi®


What should I tell my Healthcare Professional before taking Jakafi?

Before taking Jakafi, tell your Healthcare Professional about all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had tuberculosis (TB) or have been in close contact with someone who has TB, have or had hepatitis B, have or had liver or kidney problems, are on dialysis, had skin cancer, or have any other medical condition.

Especially tell your Healthcare Professional if you take medicines for fungal infections, bacterial infections, or HIV/AIDS. Taking Jakafi with certain other medicines may affect how Jakafi works. Women should not take Jakafi while pregnant or planning to become pregnant, or if breast-feeding.


What dose of Jakafi should I take?

Your Healthcare Professional will determine the appropriate dose of Jakafi for you by taking several factors into account, including:

  • The results of your blood work
  • Certain medical conditions you may have
  • Other medications you may be taking
Image of bottle of Jakafi® ruxolitinib (tablets) – 15 mg.

Jakafi comes in different dosage strengths—5 mg, 10 mg, 15 mg, 20 mg, and 25 mg—as shown below. This is because different people need different doses and dosing may change during treatment.

  • Jakafi® ruxolitinib 5 mg tablet
  • Jakafi® ruxolitinib 10 mg tablet
  • Jakafi® ruxolitinib 15 mg tablet
  • Jakafi® ruxolitinib 20 mg tablet
  • Jakafi® ruxolitinib 25 mg tablet

Be sure to take the dose you were prescribed and as often as prescribed, following your Healthcare Professional’s instructions. If you take more than the prescribed dose, call your Healthcare Professional or go to the nearest hospital emergency department right away. Take the bottle of Jakafi with you.


What is the recommended starting dose for intermediate or high-risk myelofibrosis?

For intermediate or high-risk myelofibrosis (MF), the recommended starting dose is based on your platelet counts. Before beginning treatment, your Healthcare Professional will perform a complete blood count to determine the appropriate dose. For most patients, the initial dose will be taken twice a day by mouth. Some patients may take Jakafi once a day.

During treatment, your Healthcare Professional may check your blood cell counts regularly to make sure they don’t become too low. Depending on how you respond to Jakafi, your Healthcare Professional may raise or lower the dose to help maintain appropriate blood count levels and/or treat your myelofibrosis. In some instances, your Healthcare Professional may have to temporarily stop your treatment with Jakafi.


How do I take Jakafi?

Take Jakafi exactly as instructed by your Healthcare Professional. For most patients, the starting dose of Jakafi is 1 tablet taken twice a day by mouth. In certain cases, a Healthcare Professional may start a patient at a lower dose or temporarily reduce the dose of Jakafi to once a day. It is important to take each dose of Jakafi as prescribed because the medicine in Jakafi must stay in your body for a certain amount of time to work effectively.

Graphic of medication bottle and pills

Always follow your Healthcare Professional’s directions. In certain cases, your Healthcare Professional may start you at a lower dose or temporarily reduce your dose of Jakafi to once a day. Always follow your Healthcare Professional’s directions.

Graphic of clock

Be sure you take your medicine at about the same time each day. It may help you remember to take your Jakafi if you take it at the same time as you perform another daily activity, like brushing your teeth.

Graphic of glass and grapefruit crossed out – indicating not to drink grapefruit juice while taking Jakafi

Do not drink grapefruit juice while taking Jakafi. Grapefruit juice can affect the amount of Jakafi in your blood. You can take Jakafi with or without food.

If you miss a dose of Jakafi, take your next dose as scheduled. Do not take an additional dose. If you take too much Jakafi, call your Healthcare Professional or go to the nearest hospital emergency room right away. Take the bottle of Jakafi with you.


How do I know if I’m taking the right dose of Jakafi?

Each person with MF is unique, and your Healthcare Professional will determine the optimal dosage strength of Jakafi that’s just right for you. While your response to Jakafi is being monitored, it may be possible to increase your dosage of Jakafi to provide improved or additional benefit. This is a conversation you should have with your Healthcare Professional.


How will I get Jakafi?

You will not be able to pick up Jakafi at a local pharmacy. Jakafi will come to you from a specialty pharmacy.

It is important that you let your local pharmacist know that you are taking Jakafi, and it is also important to tell the specialty pharmacy about any other medicines, vitamins, and supplements you are taking. That way your pharmacist can help you avoid any possible interactions between drugs.

For more information about getting your Jakafi prescription filled, contact IncyteCARES, the support program for eligible* patients taking Jakafi. You can call IncyteCARES at 1-855-4-Jakafi (1-855-452-5234) or visit IncyteCARES.com.

*Terms and conditions apply.

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Sue has been taking Jakafi since 2012

Discover how Sue’s MF symptoms prompted her to talk to her Healthcare Professional about moving her treatment journey forward with Jakafi.

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Important Safety Information

Indications and Usage

Jakafi is a prescription medicine used to treat people with polycythemia vera who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it.

Jakafi is also used to treat certain types of myelofibrosis.

Important Safety Information

Jakafi can cause serious side effects, including:

Low blood counts: Jakafi® (ruxolitinib) may cause your platelet, red blood cell, or white blood cell counts to be lowered. If you develop bleeding, stop taking Jakafi and call your healthcare provider. Your healthcare provider will perform blood tests to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Tell your healthcare provider right away if you develop or have worsening symptoms such as unusual bleeding, bruising, tiredness, shortness of breath, or a fever.

Infection: You may be at risk for developing a serious infection during treatment with Jakafi. Tell your healthcare provider if you develop any of the following symptoms of infection: chills, nausea, vomiting, aches, weakness, fever, painful skin rash or blisters.

Skin cancers: Some people who take Jakafi have developed certain types of non-melanoma skin cancers. Tell your healthcare provider if you develop any new or changing skin lesions.

Increases in cholesterol: You may have changes in your blood cholesterol levels. Your healthcare provider will do blood tests to check your cholesterol levels during your treatment with Jakafi.

The most common side effects of Jakafi include: low platelet count, low red blood cell counts, bruising, dizziness, headache.

These are not all the possible side effects of Jakafi. Ask your pharmacist or healthcare provider for more information. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Before taking Jakafi, tell your healthcare provider about: all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had tuberculosis (TB) or have been in close contact with someone who has TB, have or had hepatitis B, have or had liver or kidney problems, are on dialysis, had skin cancer, or have any other medical condition. Take Jakafi exactly as your healthcare provider tells you. Do not change your dose or stop taking Jakafi without first talking to your healthcare provider. Do not drink grapefruit juice while on Jakafi.

Women should not take Jakafi while pregnant or planning to become pregnant, or if breast-feeding.

Please see the Full Prescribing Information, which includes a more complete discussion of the risks associated with Jakafi.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

You may also report side effects to Incyte Medical Information at 1-855-463-3463.