Polycythemia Vera

Taking Jakafi


What should I tell my Healthcare Professional before taking Jakafi?

Before taking Jakafi® (ruxolitinib), tell your Healthcare Professional about all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had tuberculosis (TB) or have been in close contact with someone who has TB, have or had hepatitis B, have or had liver or kidney problems, are on dialysis, have high cholesterol or triglycerides, had skin cancer, or have any other medical condition.

Especially tell your Healthcare Professional if you take medicines for fungal infections, bacterial infections, or HIV/AIDS. Taking Jakafi with certain other medicines may affect how Jakafi works. Women should not take Jakafi while pregnant or planning to become pregnant, or if breast-feeding.

Professional Perspective:

How Do I Take Jakafi?

Find out how patients can work with their Healthcare Professional to ensure they are prescribed the dose of Jakafi that is appropriate for their particular circumstances.

Watch Now

What dose of Jakafi should I take?

Your Healthcare Professional will determine the appropriate dose of Jakafi for you by taking several factors into account, including:

  • The results of your blood work
  • Certain other medical conditions you may have
  • Other medications you may be taking
Image of bottle of Jakafi® ruxolitinib (tablets) – 10 mg.

Jakafi comes in different dosage strengths— 5 mg, 10 mg, 15 mg, 20 mg, and 25 mg—as shown below. This is because different people need different doses and dosing may change during treatment.

  • Jakafi® ruxolitinib 5 mg tablet
  • Jakafi® ruxolitinib 10 mg tablet
  • Jakafi® ruxolitinib 15 mg tablet
  • Jakafi® ruxolitinib 20 mg tablet
  • Jakafi® ruxolitinib 25 mg tablet

Bottles and tablets shown are not actual size.

Be sure to take the dose you were prescribed and as often as prescribed, following your Healthcare Professional’s instructions. If you take more than the prescribed dose, call your Healthcare Professional or go to the nearest hospital emergency department right away. Take the bottle of Jakafi with you.


What is the recommended starting dose for adults with polycythemia vera who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it?

For most patients with polycythemia vera (PV) who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it, the recommended starting dose of Jakafi is 10 mg, taken twice daily by mouth. Your Healthcare Professional may reduce the starting dose of Jakafi if you have liver or kidney problems or if you are taking certain medications. For most people with PV, a Healthcare Professional will check blood counts before and regularly during treatment.

If your response to Jakafi is not adequate and your blood counts are not too low, your Healthcare Professional may raise your dose. If your blood counts get too low, your Healthcare Professional may lower your dose. In some instances, your Healthcare Professional may have to temporarily stop your treatment with Jakafi.


How do I take Jakafi?

Take Jakafi exactly as instructed by your Healthcare Professional. For most patients, the starting dose of Jakafi is one tablet taken twice a day by mouth. In certain cases, a Healthcare Professional may start a patient at a lower dose or temporarily reduce the dose of Jakafi to once a day. It is important to take each dose of Jakafi as prescribed.

Graphic of medication bottle and pills

Always follow your Healthcare Professional’s directions. In certain cases, your Healthcare Professional may start you at a lower dose or temporarily reduce your dose of Jakafi to once a day. Always follow your Healthcare Professional’s directions.

Graphic of clock

Be sure you take your medicine at about the same time each day. It may help you remember to take your Jakafi if you take it at the same time as you perform another daily activity, like brushing your teeth.

Graphic of glass and grapefruit crossed out – indicating not to drink grapefruit juice while taking Jakafi

Do not drink grapefruit juice while taking Jakafi. Grapefruit juice can affect the amount of Jakafi in your blood. You can take Jakafi with or without food.

If you miss a dose of Jakafi, take your next dose as scheduled. Do not take an additional dose. If you take too much Jakafi, call your Healthcare Professional or go to the nearest hospital emergency room right away. Take the bottle of Jakafi with you.


How will I get Jakafi?

You will not be able to pick up Jakafi at a local pharmacy. Jakafi will come to you from a specialty pharmacy.

It is important that you let your local pharmacist know that you are taking Jakafi, and it is also important to tell the specialty pharmacy about any other medicines, vitamins, and supplements you are taking. That way your pharmacist can help you avoid any possible interactions between drugs.

For more information about getting your Jakafi prescription filled, contact IncyteCARES, the support program for eligible* patients taking Jakafi. You can call IncyteCARES at 1-855-452-5234 or visit IncyteCARES.com.

*Terms and conditions apply. Terms of this program may change at any time.

Image of woman – Jakafi patient – talking on the phone, sitting on a park bench

Talk with a patient taking Jakafi

Register for the Incyte Mentor Program and connect with another patient taking Jakafi.

Learn How

Interested in becoming an Incyte Mentor?
Learn about the Ambassadors for Jakafi program.

Image of a Healthcare Professional sittingat a desk talking with a patient about IncyteCARES – patient support program

Already taking Jakafi? IncyteCARES is a patient support program for people taking Jakafi that offers ongoing education and resources

IncyteCARES: Connecting to Access, Reimbursement, Education and Support

Learn More
connect-patient

Connect With
a Patient
Like Cam

Connect With a
Patient Like Cam

Register for the Incyte Mentor Program and connect with another patient taking Jakafi.

Email Address

Continue Registering

Expand Collapse

INDICATIONS AND USAGE

INDICATIONS AND USAGE

Jakafi is a prescription medicine used to treat adults with polycythemia vera who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it.

Jakafi is used to treat adults with certain types of myelofibrosis.

Jakafi is also used to treat adults and children 12 years of age and older with acute graft-versus-host disease (GVHD) who have taken corticosteroids and they did not work well enough.

Important Safety Information

Jakafi can cause serious side effects, including:

Low blood counts: Jakafi® (ruxolitinib) may cause your platelet, red blood cell, or white blood cell counts to be lowered. If you develop bleeding, stop taking Jakafi and call your healthcare provider. Your healthcare provider will perform blood tests to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Tell your healthcare provider right away if you develop or have worsening symptoms such as unusual bleeding, bruising, tiredness, shortness of breath, or a fever.

Infection: You may be at risk for developing a serious infection during treatment with Jakafi. Tell your healthcare provider if you develop any of the following symptoms of infection: chills, nausea, vomiting, aches, weakness, fever, painful skin rash or blisters.

Skin cancers: Some people who take Jakafi have developed certain types of non-melanoma skin cancers. Tell your healthcare provider if you develop any new or changing skin lesions.

Increases in cholesterol: You may have changes in your blood cholesterol levels. Your healthcare provider will do blood tests to check your cholesterol levels during your treatment with Jakafi.

The most common side effects of Jakafi include: for certain types of MF and PV – low platelet or red blood cell counts, bruising, dizziness, headache, and diarrhea; and for acute GVHD – low platelet, red or white blood cell counts, infections, and fluid retention.

These are not all the possible side effects of Jakafi. Ask your pharmacist or healthcare provider for more information. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Before taking Jakafi, tell your healthcare provider about: all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had tuberculosis (TB) or have been in close contact with someone who has TB, have or had hepatitis B, have or had liver or kidney problems, are on dialysis, have high cholesterol or triglycerides, had skin cancer, or have any other medical condition. Take Jakafi exactly as your healthcare provider tells you. Do not change your dose or stop taking Jakafi without first talking to your healthcare provider.

Women should not take Jakafi while pregnant or planning to become pregnant. Do not breastfeed during treatment with Jakafi and for 2 weeks after the final dose.

Please see the Full Prescribing Information, which includes a more complete discussion of the risks associated with Jakafi.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

You may also report side effects to Incyte Medical Information at 1-855-463-3463.