Taking Jakafi®

What should you tell your Transplant Team before taking Jakafi?

Before taking Jakafi, tell your Transplant Team about all the medicines you take, including vitamins and herbal supplements, and especially medicines for fungal or bacterial infections or HIV/AIDS. Taking Jakafi with certain other medicines may affect how Jakafi works.

Tell your Transplant Team about all your medical conditions, including if you have an infection or if you have or ever had tuberculosis (or been in close contact with someone who has it), hepatitis B, liver or kidney problems, skin cancer, or high cholesterol or triglycerides, or if you are on dialysis (Jakafi should be taken after your dialysis).

You should also tell your Transplant Team if you are pregnant or planning to become pregnant, or if breast-feeding.

What dose should I take?

Take only the dose of Jakafi your Healthcare Professional prescribes, following your Healthcare Professional’s instructions.

The recommended starting dose for most patients with acute graft-versus-host disease is 5 mg taken by mouth twice a day.

Factors that your Healthcare Professional uses to start or adjust the appropriate dose of Jakafi include:

  • Results of your blood work, including liver function test
  • Other medical conditions you may have
  • Other medications you may be taking

Depending on these criteria, your Healthcare Professional may change your dose or have you stop taking Jakafi at some point. Do not change your dose or stop taking Jakafi without first talking to your Healthcare Professional. However, if you start bleeding, stop taking Jakafi and call your Healthcare Professional immediately.

If you take more than the prescribed dose, call your Healthcare Professional or go to the nearest hospital emergency department right away. Take the bottle of Jakafi with you.

Images of 5 and 10 mg pills
Images of 5 and 10 mg pills
Image of 5 mg bottle

Tablets and bottle shown are not actual size.

It is important to take the dose you were prescribed and as often as prescribed. If you miss a dose of Jakafi, take your next dose as scheduled. Do not take an additional dose.

How do I take Jakafi?

Take Jakafi exactly as your Healthcare Professional tells you. It is important to take as prescribed.

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In certain cases, your Healthcare Professional may start you at a lower dose, temporarily reduce your dose of Jakafi, or interrupt or stop your dose. Always follow your Healthcare Professional’s directions.

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It is important to take your medicine at about the same time each day. It may help you remember to take your Jakafi if you take it at the same time as you perform another daily activity, like brushing your teeth.

plate, fork and spoon graphic

You can take Jakafi with or without food.

Graphic of a spiral notebook with checklist and a pen

My Medicine Diary

This tool gives you a handy place to write down all your medicines and check them off as you take them each day—so you’re less likely to forget.

How will I get Jakafi?

If you are in the hospital, your care team will provide Jakafi for you. If you’re at home, Jakafi will come to you from a specialty or mail order pharmacy. You will not be able to pick up Jakafi at a local pharmacy. It is important to let your local pharmacist know that you are taking Jakafi and also important to tell the specialty pharmacy about any other medicines, vitamins, and supplements you are taking. That way, your pharmacists can help you avoid any possible interactions between drugs.

Image of a Healthcare Professional sitting at a desk talking on the phone about IncyteCARES – patient support program

Already taking Jakafi? IncyteCARES is a patient support program for people taking Jakafi that offers ongoing education and resources

IncyteCARES: Connecting to Access, Reimbursement, Education and Support

Learn More
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Hear From Incyte’s Experienced Nurse Educators
In this video series, our team shares their insights on common acute GVHD questions and questions related to Jakafi.

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Jakafi is a prescription medicine used to treat adults with polycythemia vera who have already taken a medicine called hydroxyurea and it did not work well enough or they could not tolerate it.

Jakafi is used to treat adults with certain types of myelofibrosis.

Jakafi is also used to treat adults and children 12 years of age and older with acute graft-versus-host disease (GVHD) who have taken corticosteroids and they did not work well enough.

Important Safety Information

Jakafi can cause serious side effects, including:

Low blood counts: Jakafi® (ruxolitinib) may cause your platelet, red blood cell, or white blood cell counts to be lowered. If you develop bleeding, stop taking Jakafi and call your healthcare provider. Your healthcare provider will perform blood tests to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Tell your healthcare provider right away if you develop or have worsening symptoms such as unusual bleeding, bruising, tiredness, shortness of breath, or a fever.

Infection: You may be at risk for developing a serious infection during treatment with Jakafi. Tell your healthcare provider if you develop any of the following symptoms of infection: chills, nausea, vomiting, aches, weakness, fever, painful skin rash or blisters.

Skin cancers: Some people who take Jakafi have developed certain types of non-melanoma skin cancers. Tell your healthcare provider if you develop any new or changing skin lesions.

Increases in cholesterol: You may have changes in your blood cholesterol levels. Your healthcare provider will do blood tests to check your cholesterol levels during your treatment with Jakafi.

The most common side effects of Jakafi include: for certain types of MF and PV – low platelet or red blood cell counts, bruising, dizziness, headache, and diarrhea; and for acute GVHD – low platelet, red or white blood cell counts, infections, and fluid retention.

These are not all the possible side effects of Jakafi. Ask your pharmacist or healthcare provider for more information. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Before taking Jakafi, tell your healthcare provider about: all the medications, vitamins, and herbal supplements you are taking and all your medical conditions, including if you have an infection, have or had tuberculosis (TB) or have been in close contact with someone who has TB, have or had hepatitis B, have or had liver or kidney problems, are on dialysis, have high cholesterol or triglycerides, had skin cancer, or have any other medical condition. Take Jakafi exactly as your healthcare provider tells you. Do not change your dose or stop taking Jakafi without first talking to your healthcare provider.

Women should not take Jakafi while pregnant or planning to become pregnant. Do not breastfeed during treatment with Jakafi and for 2 weeks after the final dose.

Please see the Full Prescribing Information, which includes a more complete discussion of the risks associated with Jakafi.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

You may also report side effects to Incyte Medical Information at 1-855-463-3463.