/* common css */
body {
    padding-bottom: 20px;
    font-family: 'OpenSans-Regular',sans-serif;
    -webkit-print-color-adjust: exact !important;
    -webkit-font-smoothing: auto !important;
}
div, p, h1, h2, h3, h4, h5, span, em, i, b, input, a {
    font-family: 'OpenSans-Regular',sans-serif;
}
p {
    margin: 0 0 10px;
}

b,
strong {
  font-weight: normal !important;
  font-family: 'OpenSans-Bold', sans-serif !important;
}

/* header*/
.top-banner-white-bg .small-dev.no-padding{
	/*padding-right: 15px;
    padding-left: 15px;*/
}
.top-banner-gray-bg .small-dev .col-sm-2.no-padding div div:nth-child(1){display: none;}
.header .top-banner-gray-bg {
background-color: #f2f2f2;font-family: 'OpenSans-Regular',sans-serif;color: #6a6a6a;
font-size: 14px;font-weight: 400;text-align: left;height: 40px;line-height: 40px;
}
.header .top-banner-white-bg {padding: 15px 0 0;}
.header .top-banner-white-bg .container {position: relative;}
.header .right-col {top: 5px;}
.header .top-banner-white-bg .right-col p.right-txt {
    padding-right: 30px;color: #6cb33f;font-size: 22px;
    font-weight: 400;line-height: 33px;text-align: right;position: absolute;
    font-family: 'OpenSans-Regular',sans-serif;
}
.header .top-banner-white-bg .right-col p {
    color: #444444;line-height: 18px;float: right;
}
.header .top-banner-white-bg .right-col p span {
    /* font-weight: 600; */
    font-family: 'OpenSans-Bold', sans-serif;}
.header .right-col {top: 5px;}
.header .top-banner-white-bg .container {position: relative;}
.header .top-banner-white-bg {padding: 15px 0 0;}
.header .top-head-txt li {
    font-family: 'OpenSans-Regular',sans-serif;color: #63bf3f;font-size: 14px;font-weight: 400;
    line-height: normal;text-align: left;border-right: 1px solid #6a6a6a;
}
.header .top-head-txt li a {color: #63bf3f;font-size: inherit;}
.header .top-head-txt li:last-child {content: "";border-right: none;}
.header .top-banner-gray-bg img {display: inline-block;margin-right: 5px; margin-bottom: 0px;}
.header .resident-txt {
    font-family: 'OpenSans-Regular',sans-serif;color: #6a6a6a;font-weight: 400;line-height: normal;text-align: left;
}
.header .top-banner-white-bg .container {position: relative;}
.subpage-header.header{/*padding-bottom: 15px;*/}
.subpage-header.header .top-banner-white-bg .small-dev.no-padding{padding-left:0px; padding-right: 0px;}
.subpage-header.header .top-banner-white-bg {
    /*padding-bottom: 15px !important;*/
}



/* hamburger-menu-item starts*/
.hamburger-menu-item .navbar-header {top: 10px;position: relative;width: 100%;}
.header .navbar-default .navbar-toggle.custom-toggle {
    border: none;padding-right: 0;margin-right: 0;outline: none;
}

.header .navbar-default .navbar-toggle {display: block;}
.navbar-toggle {
    position: relative;float: right;padding: 9px 10px;margin-top: 8px;
    margin-bottom: 8px;background-color: transparent;border-radius: 4px;
}
.header .navbar-default .navbar-brand {
    color: #6cb33f;font-size: 18px;font-weight: 400;
    text-align: left;padding: 0;float: right;
    font-family: 'OpenSans-Regular',sans-serif;
}
.navbar-brand {line-height: 20px;}
.hidden-sm {display: block !important;}
.navbar-header:after {clear: both;}
.navbar-header:before, .navbar-header:after {display: table;content: " ";}
.header .navbar-default {background-color: transparent;border: none;float: right;width: 100%;}
.navbar {position: relative;z-index: 1000;min-height: 50px;margin-bottom: 20px;}


.nav-tabs {border-bottom: 1px solid #dddddd;}
.nav {padding-left: 0;margin-bottom: 0;}
.header .custom-navbar li {width: 100%;}
.header .PV-menu {background-color: #453490;}
.nav-tabs > li {margin-bottom: -1px;}
.nav > li {position: relative;display: block;}
.header .myelofibrosis-menu {background-color: #67b03c;}
.header .GVHD-menu {background-color: #92308d;}
.header .cGVHD-menu {background-color: #C627A6;}
.header .custom-navbar .nav-tabs > li > a {
    font-size: 18px;
    /* font-weight: 700; */
    text-align: left;font-family: 'OpenSans-Bold',sans-serif;color: #fff;
    padding: 15px;display: inline-block;width: 100%;border: none;margin: 0;cursor: pointer;
}
.nav-tabs > li > a {border-radius: 4px 4px 0 0;position: relative;}
.header .custom-navbar li span {display: inline;float: left;margin-right: 5px;}

.header .navbar-default .navbar-toggle.custom-toggle span {background-color: #74b03d;pointer-events: none;}
.header .navbar-toggle.collapsed span:nth-child(2), .header .navbar-toggle.collapsed span:nth-child(4) {transform: rotate(0);}
.header .navbar-toggle span:nth-child(2) {transform: rotate(45deg);transform-origin: 10% 10%;}
.header .navbar-toggle span.icon-bar {transition: all 0.15s;width: 30px;height: 4px;}
.navbar-toggle .icon-bar {display: block;border-radius: 1px;}
.header .navbar-toggle span:nth-child(3) {opacity: 0;}
.navbar-toggle .icon-bar + .icon-bar {margin-top: 4px;}
.header .navbar-toggle span:nth-child(4) {transform: rotate(-45deg);transform-origin: 10% 90%;}
.header .navbar-toggle span.icon-bar {transition: all 0.15s;width: 30px;height: 4px;}
.navbar-toggle .icon-bar {display: block;border-radius: 1px;}
.header .top-banner-white-bg .right-col p.head-txt {
    font-family: 'OpenSans-Regular',sans-serif;
    color: #6a6a6a;
    font-size: 13px;
    font-weight: 400;
    line-height: normal;
    text-align: left;
    width: 100%;
    border-right: none;
}
.header .navbar-default .navbar-toggle:focus, .header .navbar-default .navbar-toggle:hover {background-color: transparent;}
.header .navbar-toggle.collapsed span:nth-child(3) {opacity: 1;}
.header .custom-navbar .nav-tabs > li > a:hover{border:none;background-color:transparent;text-decoration:none;}
.header .custom-navbar .nav-tabs > li > a:hover span:nth-child(2){border-bottom:1px solid #fff;}
.sr-only {
    position: absolute;width: 1px;height: 1px;padding: 0;
    margin: -1px;overflow: hidden;clip: rect(0 0 0 0);border: 0;
}
.ui-selectmenu-icon.ui-icon {
    text-indent: 0;font: normal normal normal 14px/1 FontAwesome;
    color: #999;margin-top: 2px;
}

.ui-selectmenu-text {
    color: #999;display: block;margin-right: 20px;
    overflow: hidden;text-overflow: ellipsis;font-size: 16px;
    /* font-weight: 600; */
    font-family: 'OpenSans-Bold', sans-serif;
}
.ui-icon-triangle-1-s:before {content: "\f078";}
.ui-menu .ui-menu-item-wrapper {position: relative;padding: 3px 1em 3px 0.4em;}
.ui-menu .ui-menu-item {margin: 0;cursor: pointer;
    list-style-image: url(data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7);
}
.display-none {display: none;}

/* hamburger-menu-item end */

/* footer */
.footer {border-top: 2px solid #b3b3b3;background: white;}
.footer-container {background: none repeat scroll 0 0 #FFFFFF;width: 100%;padding-bottom: 8px;}
.footer-wrapper {
    padding: 18px 0 0px 25px;
    color: #6C6C6C;
    font-size: 11px;
    border-bottom: 1px solid #F8F8F8;
    /* font-family: 'Open Sans',sans-serif; */
}
.footer-links {margin-bottom: 20px;}
.footer-wrapper .footer-links a, .footer-wrapper .footer-links span {/*float: left;margin: 0 15px 0 0;*/}
.footer-links a {
    color: #67A43E;
    font-family: 'OpenSans-Bold', sans-serif;
    font-size: 11px;
    display: inline-block;
    /* font-weight: 600; */
    font-weight: normal;
}
.footer-wrapper .footer-links a {color: #6EB43F;}
.footer-wrapper .footer-links a, .footer-wrapper .footer-links span {float: left;margin: 0 10px 0 0;}
.footer-wrapper span {
	color: #7C2A90;
    /* font-family: 'Open Sans',sans-serif; */
    font-size: 12px;
}
.footer-wrapper .social-icon p {
    color: #444444;font-size: 18px;letter-spacing: 0;line-height: 22px;
}
.footer-wrapper .social-icon a {
    margin-right: 15px;display: inline-block;border-radius: 50%;
}
.footer-links {margin-bottom: 20px;}
.footer-wrapper .social-icon p {
    color: #444444;font-size: 18px;letter-spacing: 0;line-height: 22px;
}
.follow-fbbtn-img {
    background-image: url(../images/Facebook_footer_icon.png);
    background-repeat: no-repeat;background-position: center;background-size: 100%;
    width: 45px;height: 45px;display: block;
}
.follow-ytbtn-img {
    background-image: url(../images/YouTube_footer_icon.png);
    background-repeat: no-repeat;background-position: center;background-size: 100%;
    width: 44px;height: 45px;display: block;
}

.follow-btn .off,
.follow-btn:hover .on {display: inline-block;}

.follow-btn .on,
.follow-btn:hover .off {
    display: none;
}
.follow-fbbtn-img:hover{background-image:url(../images/Facebook_footer_icon-hover.png);background-repeat:no-repeat;background-position:center;background-size:100%;width:45px;height:45px;display:block;}
.follow-ytbtn-img:hover{background-image:url(../images/YouTube_footer_icon-hover.png);background-repeat:no-repeat;background-position:center;background-size:100%;width:45px;height:45px;display:block;}
.footer-wrapper .nav-item a:hover{background: transparent;}


/* modal */
.offramp-modal {z-index: 1500;/*background-color: rgba(0,0,0,0.78);*/background-color:rgba(0,0,0,0.56);}
.modal {position: fixed;top: 0;right: 0;bottom: 0;left: 0;overflow: auto;overflow-y: scroll;}
.fade {opacity: 0;-webkit-transition: opacity 0.15s linear;transition: opacity 0.15s linear;}
.modal.fade .modal-dialog {-webkit-transform: translate(0,0);-ms-transform: translate(0,0);transform: translate(0,0);
-webkit-transition: -webkit-transform 0.3s ease-out;-moz-transition: -moz-transform 0.3s ease-out;-o-transition: -o-transform 0.3s ease-out;transition: transform 0.3s ease-out;
}
.modal.in .modal-dialog {-webkit-transform: translate(0,0);-ms-transform: translate(0,0);transform: translate(0,0);}
.modal-dialog {z-index: 1050;padding: 10px;margin-right: auto;margin-left: auto;}
.modal-content {position: relative;background-color: #ffffff;border: 1px solid #999999;border: 1px solid rgba(0,0,0,0.2);border-radius: 6px;outline: none;-webkit-box-shadow: 0 3px 9px rgb(0 0 0 / 50%);box-shadow: 0 3px 9px rgb(0 0 0 / 50%);background-clip: padding-box;
}

.offramp-modal .modal-header {padding: 0;border: none;min-height: 16.428571429px;}
.offramp-modal .close-btn {position: absolute;top: -10px;right: -10px;cursor: pointer;}
.offramp-modal .modal-body {padding-top: 0;border: none;}
.modal-body { position: relative; padding: 20px;}
.offramp-modal .head {padding: 0;color: #492f92;font-size: 29.65px;
    /* font-weight: 700; */
    line-height: normal;text-align: center;font-family: 'OpenSans-Bold', sans-serif;}

.offramp-modal .modal-body .modal-txt {color: #444444;font-size: 15.93px;
    /* font-weight: 600; */
    line-height: normal;text-align: center;width: 60%;margin: 0 auto;font-family: 'OpenSans-Bold', sans-serif;}
.offramp-modal .modal-footer {text-align: center;border: none;padding-bottom: 40px;margin-top: 0;}
.modal-footer {padding: 19px 20px 20px;}
.offramp-modal .modal-footer .btn-link {background-color: #6eb43f;color: #fefefe;font-size: 23.89px;
    /* font-weight: 700; */
    line-height: normal;text-align: center;padding: 5px 15px;margin-right: 15px;font-family: 'OpenSans-Bold', sans-serif;
}

/* cookie banner */
.cookie-policy {
    width: 100%;
    border-bottom: 1px solid #B2B2B2;
    font-family: 'Uni57Condensed';
    font-size: 14px;
    color: #FFF;
    background: #4C4B49;
}
.cookie-policy  div {
    margin: 0 auto;
    padding: 8px 0;
    width: 90%;
    display: table;
}
.cookie-policy span {
    display: table-cell;
    vertical-align: middle;
    padding: 0 5px 0 0;
}
.cookie-policy a {
    color: #6cb33f;
}
.cookie-policy span.underline {
    display: inline-block;
    text-decoration: underline;
    vertical-align: initial;
    padding: 0;
}
.cookie-policy .cc-policy-button, .cookie-policy .cc-policy-button:hover, .cookie-policy .cc-policy-button:visited {
    background-color: #6cb33f;
    color: #FFF;
    padding: 5px 8px;
    cursor: pointer;
}
.eu-cookie-compliance-secondary-button {
    cursor: pointer;
    border: none;
    background: none;
    margin-top: 1em;
    padding: 0 8px;
    vertical-align: middle;
}

#sliding-popup.sliding-popup-top {
    position: relative;
    text-align: left;
}
.sticky-container.fixed {
    top: 80px !important;position: fixed;z-index: 1100;
}
.sticky-container {
    position: absolute;
    right: 0px;
    top: 570px;
    z-index: 1000;
    border: 1px solid #6cb33f;
    border-right: 0px;
    background-color: #FFFFFF;
}
ul.sticky {
    margin: 0;
    padding: 0;
    width: 75px;
}
.sticky li {
    list-style-type: none;
    background-color: #fff;
    color: #efefef;
    height: 43px;
    -webkit-transition: all 0.25s ease-in-out;
    -moz-transition: all 0.25s ease-in-out;
    -o-transition: all 0.25s ease-in-out;
    transition: all 0.25s ease-in-out;
    text-align: center;
}
.sticky .share-label {
    font-family: 'OpenSans-Bold', sans-serif;
    color: #492f91;
    font-size: 17.96px;
    /* font-weight: 600; */
    line-height: 59.852px;
    transform: scaleY(1.0024);
    margin-bottom: 10px;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(1) {
    background-color: #453490;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(2) {
    background-color: #4e3e96;
}
.offramp-link {
    cursor: pointer;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(1) {
    background-color: #67b03c;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(2) {
    background-color: #73b749;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(3) {
    background-color: #7abb53;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(4) {
    background-color: #81be5c;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(5) {
    background-color: #88c265;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(6) {
    background-color: #91c66f;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(7) {
    background-color: #98ca7a;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(8) {
    background-color: #9ece82;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(9) {
    background-color: #a7d18b;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(10) {
    background-color: #aed992;
}
.header .menu-item-list .tab-content .tab-pane.myelofibrosis-menu ul li .list-sub-menu li:nth-child(11) {
    background-color: #bde6a2;
}
.header .menu-item-list .tab-content .tab-pane.GVHD-menu ul li .list-sub-menu li:nth-child(1) {
    background-color: #a22c9f;
}
.header .menu-item-list .tab-content .tab-pane.GVHD-menu ul li .list-sub-menu li:nth-child(2) {
    background-color: #b533b2;
}
.header .menu-item-list .tab-content .tab-pane.GVHD-menu ul li .list-sub-menu li:nth-child(3) {
    background-color: #c538c2;
}
.header .menu-item-list .tab-content .tab-pane.GVHD-menu ul li .list-sub-menu li:nth-child(4) {
    background-color: #d440d1;
}
.header .menu-item-list .tab-content .tab-pane.GVHD-menu ul li .list-sub-menu li:nth-child(5) {
    background-color: #e447e1;
}
.header .menu-item-list .tab-content .tab-pane ul li:last-child {
    position: relative;
}
.sliding-popup-bottom, .sliding-popup-top {
    z-index: 1;
}

.header .menu-item-list .tab-content .tab-pane ul li .list-sub-menu {
    position: absolute;
    top: auto;
    left: 0;
    background: #453490;
    z-index: 9;
    text-align: left;
    width: 255px;
    padding-top: 0;
}
.header .menu-item-list .tab-content .tab-pane ul {
    padding: 0;
    margin: 0;text-align: center;
}
.pv-container .sticky li a {
    display: inline-block;
    border-radius: 50%;
}
.header .custom-navbar li span {
    display: inline;
    margin-right: 5px;
}

.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(1) {
    background-color: #453490;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(2) {
    background-color: #4e3e96;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(3) {
    background-color: #58499B;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(4) {
    background-color: #6052a0;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(5) {
    background-color: #6a5da5;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(6) {
    background-color: #7467ac;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(7) {
    background-color: #7d71b2;
}
.PV-menu ul ul#subMenu8 li.get-link:nth-child(8), ul#mfsubMenu8 li.get-link:nth-child(8) {
    font-style: italic;
}

.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(8) {
    background-color: #857bb7;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(9) {
    background-color: #8f84bb;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(10) {
    background-color: #978BC0;
}
.header .menu-item-list .tab-content .tab-pane.PV-menu ul li .list-sub-menu li:nth-child(11) {
    background-color: #a498cf;
}
.header .custom-navbar .nav-tabs > li.active > a, .header .custom-navbar .nav-tabs > li.active > a:hover, .header .custom-navbar .nav-tabs > li.active > a:focus {
    background-color: transparent;
    color: #fff;
    border: none;
}

.header .menu-item-list .tab-content .tab-pane ul li .list-sub-menu a {
    padding: 0;
    width: 100%;
    display: block;
}
.offramp-modal .modal-header img{
    width: 100%;
}

.pi-pi .middle-section hr {
    margin-top: 20px;
    margin-bottom: 20px;
}
.footer-wrapper .footer-links a:hover{text-decoration: underline;}
.cgvhd-section .ac-gvhd-links .c-gvhd-link {
    width: 35%;
    margin-left: 3%;
    text-align: center;
}
.isi-wrapper a.offramp-link:hover{text-decoration: underline;}
.header .custom-navbar .nav-tabs > li > a {
    font-size: 18px;
    /* font-weight: 700; */
    text-align: left;
    font-family: 'OpenSans-Bold',sans-serif;
    color: #fff;
    padding: 15px;
    display: inline-block;
    width: 100%;
    border: none;
    margin: 0;
    cursor: pointer;
}
.section-404-500 {
    /*margin-top: 16px;*/
}

.sitemap .top-banner-white-bg {
    padding-bottom: 15px;
}
.meet-mentor-box-expanded-text a{margin-left: -45px;}
.isi-wrapper sup.tm {
    top: -2px;
    font-size: 85% ;
}
.isi-wrapper sup {
    font-size: 63%;
    top: -5px;
}
.isi ul{
    padding-left: 23px;
}
.isi ul li {
    line-height: normal;
}

.isi li::marker {
    font-size: 0;
}
.isi li::before {
    content: "";    
    display: inline-block;    
    margin-left: -11px;    
    width: 4px;
    height: 4px;
    border-radius: 50%;
    background-color:  #000000;
    margin-right: 5px;
    top: -2px;
    position: relative;
}
.isi li ul li::before {    
    width: 4px;
    height: 4px;    
    border: solid 1px #000000; 
    background-color:inherit;
    margin-right: 7px;
}

.isi p.b-heading-mb0 {
  margin-bottom: 0;
}
.isi a[href^=tel]{
    text-decoration:none;
    color:inherit !important;
    pointer-events: none;
    cursor: default;
}
p.ph-bold-remove a {
    font-family: 'OpenSans-Regular', sans-serif !important;
}
.isi-wrapper .indication h4 {
    text-transform: inherit;
}
li.mb10 {
    margin-bottom: 10px !important;
}
a:focus {
    outline: none !important;
}
@media only screen and (min-device-width: 768px) and (max-device-width: 1024px) and (orientation: portrait) {
    #isi_section {
        margin-top: 15px;
    }
}