Determining prognosis can be challenging because myelofibrosis has a very heterogeneous presentation. As the clinical understanding of myelofibrosis has evolved, a variety of prognostic systems have been developed.1
The International Working Group for Myelofibrosis Research and Treatment (IWG-MRT) has developed the International Prognostic Scoring System (IPSS) and the Dynamic International Prognostic Scoring System (DIPSS), used to determine a patient's risk group at diagnosis and over time, respectively.1,2
The final score may be related to a patient's prognosis.1,2
- Cervantes F, Dupriez B, Pereira A, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood. 2009;113:2895-2901.
- Passamonti F, Cervantes F, Vannucchi AM, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115:1703-1708.