What is Jakafi?
Jakafi is a prescription medicine used to treat people with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post–polycythemia vera myelofibrosis and post–essential thrombocythemia myelofibrosis.
It is not known if Jakafi is safe or effective in children.
What should I tell my healthcare provider before taking Jakafi?
Before taking Jakafi, tell your healthcare provider if you:
- have an infection
- have or have had liver or kidney problems
- are on dialysis. Jakafi should be taken after your dialysis
- have any other medical conditions
- are pregnant or plan to become pregnant. It is not known if Jakafi will harm your unborn baby
- are breast-feeding or plan to breast-feed. It is not known if Jakafi passes into your breast milk. You and your healthcare provider should decide if you will take Jakafi or breastfeed. You should not do both
Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Taking Jakafi with certain other medicines may affect how Jakafi works.
Especially tell your healthcare provider if you take medicine for:
- Fungal infections
- Bacterial infections
Ask your healthcare provider or pharmacist if you are not sure if your medicine is one listed above.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take Jakafi?
- Take Jakafi exactly as your healthcare provider tells you
- Do not change your dose or stop taking Jakafi without first talking to your healthcare provider
- You can take Jakafi with or without food
- Jakafi may also be given through certain nasogastric tubes
- Tell your healthcare provider if you cannot take Jakafi by mouth. Your healthcare provider will decide if you can take Jakafi through a nasogastric tube
- Ask your healthcare provider to give you specific instruction on how to properly take Jakafi through a nasogastric tube
- Do not drink grapefruit juice while taking Jakafi. Grapefruit juice can affect the amount of Jakafi in your blood
- If you take too much Jakafi, call your healthcare provider or go to the nearest hospital emergency room department right away. Take the bottle of Jakafi with you
- If you miss a dose of Jakafi, take your next dose at your regular time. Do not take 2 doses at the same time
- You will have regular blood tests during your treatment with Jakafi. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests
What are the possible side effects of Jakafi?
Jakafi can cause serious side effects including:
Low blood counts: Jakafi may cause your platelet, red blood cell, or white blood cell counts to be lowered. If you develop bleeding, stop taking Jakafi and call your healthcare provider. Your healthcare provider will perform blood tests to check your blood counts before you start Jakafi and regularly during your treatment. Your healthcare provider may change your dose of Jakafi or stop your treatment based on the results of your blood tests. Tell your healthcare provider right away if you experience:
- unusual bleeding
- shortness of breath
Infection: You may be at risk for developing a serious infection while taking Jakafi. Tell your healthcare provider if you develop symptoms such as:
- painful skin rash or blisters
The most common side effects of Jakafi include:
Tell your healthcare provider about any side effect that bothers you or that does not go away.
These are not all the possible side effects of Jakafi. Ask your healthcare provider or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
How should I store Jakafi?
- Store Jakafi at room temperature between 68°F and 77°F (20°C and 25°C)
Keep this and all medicines out of the reach of children.
General information about the safe and effective use of Jakafi
Medicines are sometimes prescribed for purposes other than those listed in Patient Information. Do not use Jakafi for a condition for which it is not prescribed. Do not give Jakafi to other people, even if they have the same symptoms you have. It may harm them.
This site summarizes the most important information about Jakafi. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information that is written for healthcare professionals.
For more information call 1-855-463-3463.
What are the ingredients in Jakafi?
Active ingredient: ruxolitinib.
Inactive ingredients: microcrystalline cellulose, lactose monohydrate, magnesium stearate, colloidal silicon dioxide, sodium starch glycolate, povidone and hydroxypropyl cellulose.
This Patient Information has been approved by the US Food and Drug Administration.